PC versionXbox 360WIP Fans have made a PC version. Some are still early, so read the project page first.
Fans took Destroy All Humans: Path of the Furon apart and rebuilt it so it runs natively on a computer, often with widescreen, higher frame rates and mods. Here are the 2 projects we know about:
Destroy all humans Path of the Furon Recompiled with Rexglue-SDK
recomp aimed to recompile destroy all humans path of the furon