PC versionDS / NDS / Nintendo DSWIP Fans have made a PC version. Some are still early, so read the project page first.
Fans took Pokémon SoulSilver apart and rebuilt it so it runs natively on a computer, often with widescreen, higher frame rates and mods. Here is the project we know about:
A recomp of Pokemon Soul Silver for single screen devices. macOS support thanks to DarthMDev.