PC version Fans have made a PC version. Some are still early, so read the project page first.
Fans took Resident Evil Gaiden apart and rebuilt it so it runs natively on a computer, often with widescreen, higher frame rates and mods. Here is the project we know about:
Native static C/C++ recompilation of Resident Evil Gaiden (GBC) for PC with True Widescreen, 2D Dynamic Lighting, Retro Horror Shaders, and HD Texture Pack support