PC version Fans have made a PC version. Some are still early, so read the project page first.
Fans took Spider-Man 2 apart and rebuilt it so it runs natively on a computer, often with widescreen, higher frame rates and mods. Here is the project we know about:
An experimental native recompilation of Spider-Man 2 for the original Xbox, bringing the classic open-world adventure to modern Windows through an evolving native implementation.