PC versionPC Fans have made a PC version. Some are still early, so read the project page first.
Fans took The Binding of Isaac: Rebirth (The Browsing of Isaac) apart and rebuilt it so it runs natively on a computer, often with widescreen, higher frame rates and mods. Here is the project we know about:
The Binding of Isaac: Repentance+ recompiled to WebAssembly, playable in the browser.